Study

Abstract Summary: This study investigates the familial risk of varicocele by examining the first-degree relatives of men with known varicoceles. Among 49 men with clinical varicocele who presented with infertility, testicular pain, or scrotal swelling between June 2008 and May 2009, 66 first-degree relatives were screened. Compared to a control group of 100 men without varicocele, the prevalence of palpable varicocele in first-degree relatives (33.9%) was significantly higher (3 times) than in the control group (12%). Fathers (21.1%) and brothers (36.2%) of patients with varicocele showed the highest prevalence. The study suggests a hereditary aspect of varicocele and recommends counseling for male relatives of affected individuals regarding the increased risk. This study highlights the need for further research into the genetic causes and clinical impact of varicocele inheritance.